Registry randomised clinical trials (RRCTs) have the potential to provide pragmatic answers to important clinical questions.RRCTs can be embedded into large population-based registries or smaller single site registries to provide timely answers at a reduced cost Standard Pillow compared with traditional randomised controlled trials.RRCTs can take a
Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA
Small interfering RNAs (siRNAs) are revolutionizing the treatment of liver-associated indications.Yet, robust delivery to extrahepatic tissues remains a challenge.Conjugating lipids (e.g., docosanoic acid [DCA]) to siRNA supports extrahepatic delivery, but tissue accumulation remains lower than that achieved in liver by approved siRNA therapeutics.
Feasibility of Low Latency, Single-Sample Delay Resampling: A New Kriging Based Method
Wireless sensor systems often fail to provide measurements with uniform time spacing.Measurements can be delayed or even miss completely.Resampling to uniform intervals is necessary to satisfy the requirements of subsequent signal processing.Common resampling algorithms, based on symmetric finite impulse response (FIR) filters, entail a group delay
Evaluation of Aminopolycarboxylate Chelators for Whole-Body Clearance of Free 225Ac: A Feasibility Study to Reduce Unexpected Radiation Exposure during Targeted Alpha Therapy
Actinium-225 (225Ac) is a promising radionuclide used in targeted alpha therapy (TAT).Although 225Ac labeling of bifunctional chelating ligands is effective, previous in vivo studies reported that free 225Ac can be released from the drugs and that such free 225Ac is predominantly accumulated in the liver and could cause unexpected toxicity.To accel